Articles & Publications

The following publications discuss leptin and leptin sensitization.

Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. Nat Med. 2019;25(4):575-582.

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes. 2018 Nov;67(11):2456-2465. doi: 10.2337/db18-0146. Epub 2018 Aug 28.

Friedman J. The long road to leptin. J Clin Invest. 2016;126(12):4727–4734.

Lee J, Liu J, Feng X, Salazar Hernández MA, Mucka P, Ibi D, Choi JW, Ozcan U. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Nat Med. 2016;22(9):1023-1032.

Liu J, Lee J, Salazar Hernández MA, Mazitschek R, Ozcan U. Treatment of Obesity with Celastrol. Cell. 2015;161:999–1011.

Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG, Ozcan U. Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance. Cell Metabolism. 2009;9:35–51.