Obesity and Obesity-Related Diseases
Obesity puts patients at higher risk for more than 50 related diseases, from heart disease and abnormalities in lipids (low HDL, high triglycerides), to elevated blood pressure, insulin resistance and type 2 diabetes, fatty liver disease and non-alcoholic steatohepatitis, sleep apnea, arthritis, and certain weight-related cancers.1
Obesity is a resilient and complex chronic disease that is a risk factor for many cardiovascular and metabolic conditions. Making heart-healthy lifestyle changes, including changes to help achieve a healthy weight, is the recommended approach for addressing these conditions. However, lifestyle changes are not always enough.1 ERX Pharmaceuticals seeks to address the unmet need for obesity treatment as an adjunct to lifestyle modification through the development of first-in-class weight loss therapies, which may potentially decrease the burden of some weight-related comorbidities.
Obesity is associated with many other health risks, including cardiovascular disease, hypertension, type 2 diabetes, asthma, non-alcoholic fatty liver disease, and some cancers.1 Early research has led to the belief that leptin resistance may play a role in obesity, diabetes, and other related diseases.
- US Department of Health and Human Services National Heart, Lung and Blood Institute. Managing Overwieght and Obesity in Adults. 2013.