Leptin and Diabetes
Insulin is a hormone produced by the pancreas that allows the body to utilize glucose in the blood for energy. Type 2 diabetes is characterized by insulin resistance, in which the body is unable to properly respond to and utilize insulin. This leads to rising blood sugar levels and, depending on the degree of insulin resistance, a need for injected insulin or other treatments to maintain normal glucose levels.
In addition to moderating energy conservation and expenditure, growing evidence suggests that the leptin hormone is a mediator of insulin secretion and sensitivity, thereby playing a key role in glycemic control3. ERX-2000 is a class of leptin sensitizing compound that is currently in the discovery stage for the treatment of type 2 diabetes. To date, ERX-2000 has shown anti-diabetic activity and weight-lowering ability in preclinical animal models.